Ayad Abed Ali Al-Hamashi
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, IraqPublications
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Research Article
Design, synthesis, and evaluation of activity against breast cancer cells of new naphthalene derivatives as potential sirtuin enzymes inhibitors
Author(s): Hayjaa Mohessen Mosa* and Ayad Abed Ali Al-Hamashi
Epigenetic modifications are potentially therapeutic targets because of their reversibility in somatic inheritability patterns. The sirtuin enzyme family is a Nicotinamide Adenine Dinucleotide (NAD+)-dependent histone deacetylase. Sirtuins have been associated with the pathogenesis of cancer due to their function in gene expression, making them an interesting therapeutic target. In the current study, several naphthalene-containing molecules were designed. The molecular docking Glide software from Schrodinger Inc. was used to evaluate the virtual interactions of the designed compounds with sirtuin enzymes. Compounds with acceptable docking scores were nominated for organic synthesis. The new naphthalene derivatives were synthesized and characterized via FTIR and NMR spectroscopy. A preliminary antiproliferative study over aggressive, poorly differentiated, and multi-treatment resistant.. Read More»
Editors List
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Prof. Elhadi Miskeen
Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia
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Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
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Sudhakar Tummala
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
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Alphonse Laya
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
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Fava Maria Giovanna
Onkologia i Radioterapia peer review process verified at publons
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