EL Shaimaa Shabana
Department of Microbiology, Mansoura University, Mansoura, EgyptPublications
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Research Article
Amygdalin folic acid nanoparticles inhibits the proliferation of breast cancer and enhances the effect of radiotherapy through modulation of tumor promoting factors/immunosuppressive modulators in vitro
Author(s): Mostafa Askar*, Ibrahim Y Abdelrahman, Gharieb S El-sayyad, Mona S Guida, EL Shaimaa Shabana and Eman Khalifa
Purpose: Breast Cancer (BC) cells often develop multiple mechanisms of chemo and radio-resistance during tumor progression, which is the major reason for the failure of breast cancer therapy. Targeted nano-medicines have tremendous therapeutic potential in BC treatment over their free drug counterparts. Searching for chemo-and radio sensitizers to overcome such resistance is therefore urgently required. The goal of this study is to evaluate and compare the radio-sensitizers efficacy of Amygdalin-Folic acid-nanoparticles (Amy-F) on MCF-7 and MDA-MB-231 cells. Methods: The effects of Amy-F on MCF-7 and MDA-MB-231 cells proliferation and IC50 were assessed using MTT assay. The expression of proteins involved in several mechanisms induced by Amy-F in MCF-7 and MDA-MB-231 cells, including growth inhibition, apoptosis, tumor growth regulators, imm.. Read More»
Editors List
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Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
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Sudhakar Tummala
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
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Alphonse Laya
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
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Fava Maria Giovanna
- Manuprasad Avaronnan
Google Scholar citation report
Citations : 558
Onkologia i Radioterapia received 558 citations as per Google Scholar report
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