J. Usta

Faculty of Medicine, Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon

Publications

  • Research Article   
    Protective effect of Sorafenib against 1,2-Dimethylhydrazine-induced colorectal cancer in Balb/c Mice
    Author(s): M. Al Hassan, M. Al Battal, J. Usta and J. Borjac*

    Colorectal Cancer (CRC) is the third leading cause of cancer death in the world whose incidence is progressively rising in developing nations. It is treated with both chemotherapeutic and immunotherapeutic agents. Sorafenib is a broad-spectrum multikinase inhibitor proven to be effective in treating different types of carcinoma, including liver, thyroid, renal, and breast cancers. This study aimed to investigate the effect of Sorafenib against 1,2-dimethylhydrazine (DMH)-induced CRC in mice. Mice were injected with DMH (20 mg/kg) over 12 weeks to induce the cancer. Mice were treated with Sorafenib (30 mg/Kg for 5 days). Colon tissues were examined by histological analysis, and gene expression level of key players involved in the Wnt signaling pathway were assessed using RT-PCR. Our results showed that Sorafenib restored the normal histology and structu.. Read More»

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Awards Nomination

Editors List

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh

     

     

     

  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis

     

  • Fava Maria Giovanna

     

  • Manuprasad Avaronnan

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