Mahendra Kumar Kalappan

Department of General Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Thandalam, Chennai, Tamil Nadu, India

Publications

• Research Article   
  Metformin and anti-cancer effects: Systematic insights into its therapeutic potential
  Author(s): Nithesh Babu Ramesh*, Abinaya Srinivasa Rangan, Vimal Kumar Anandan Govindaraj, Suhail Aamir, Gnanadeepan Thirugnanam and Mahendra Kumar Kalappan
  
  Background: Metformin is a very widely prescribed antidiabetic drug that has recently received broad attention for its potential anticancer properties. New evidence suggests multifarious effects of metformin on cancer cell metabolism, growth, and survival. Objective: The objective of this systematic review is to take a deeper look and synthesize available research into the anti-cancer effects of metformin, underlining its treatment potential across different types of cancers. Methods: A systematic literature search up to June 2024 in PubMed, Scopus, Medline, and EMBASE has been done. The literature search primarily includes clinical trials, pre-clinical studies, and meta-analyses on the examination of anticancer mechanisms and efficacy of metformin. Extracted data have been analysed according to the criteria, most importantly on how metformin would influence cancer incidence and rate .. Read More»
  

  Abstract PDF