Mayada T. Abdulrahman
Microbiology Department, College of Medicine, University of Basrah, Basrah, IraqPublications
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Research Article
Monoclonal pattern of T-Lymphocytes and B-Lymphocytes receptors gene rearrangement in Acute Lymphocytic Leukemia in Basrah
Author(s): Nibras S. Al-Ammar*, Hermann Kreyenberg and Mayada T. Abdulrahman
Paediatrics clinicians face a problem in evaluation of chemotherapy treatment used for Acute Lymphoblastic Leukaemia (ALL) patients in Iraq. They need an accurate test to evaluate the treatment. This study aimed to detect the clonality pattern of T and B lymphocytes receptors gene rearrangements in ALL patients in Basrah before chemotherapy. Bone morrow aspiration samples from 50 ALL patients used for DNA extraction followed by multiplex PCR by using 42 primers. A total of 147 bands cut from polyacrylamide gel and sent for sequencing in order to detect the pattern of receptors gene rearrangements. 15th ALL patients were found to have rearrangements in the studied genes coding for receptors of T and B lymphocytes; TCR and Ig. Ten patients have a rearrangement of Ig while 5 patients rearranged TCR. Immunoglobulin Heavy Chain (IGH) gene was rearranged in 6 patients. Some patients appeare.. Read More»
Editors List
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Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
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Sudhakar Tummala
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
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Alphonse Laya
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
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Fava Maria Giovanna
- Manuprasad Avaronnan
Onkologia i Radioterapia peer review process verified at publons
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