Muthana I. Maleek

Department of Biology, College of Sciences, University of Wasit, Iraq

Publications

• Research Article   
  Evaluation levels of sphingosine, sphingosine-1-phosphate, and interleukin 2 and 3 in leukemia patients
  Author(s): Hala F. Hassan*, Safaa A. Faraj, Muthana I. Maleek and Zainulabdeen AL-Badri
  
  Sphingosine is the major naturally occurring base present in sphingolipids. It forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid. Sphingosine-1-Phosphate (S1P) is a signaling sphingolipids, also known as glycosphingolipid. It is also referred to as a bioactive lipid mediator. The expression and localization of S1P receptors is dynamically regulated and controls immune cell trafficking. In vertebrates, S1P is found in the extracellular milieu and interacts with cell-surface receptors to regulate an array of cellular responses, including cell migration, differentiation and survival. Targeting various signaling pathways is a potential neoteric therapeutic for the treatment of leukemia. "Sphingosine and sphingosine 1 phosphate" are expressed in large amounts by leukemia cells. Leukemia is a group of blood.. Read More»
  

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