Wael Mansour Saeed

Publications

• Research Article   
  Neoadjuvant sequential short course radiotherapy and folfox versus neoadjuvant long course chemoradiation and evaluation of glascow scale sensitivity as a prognostic and predictive marker in locally advanced rectal cancer
  Author(s): Fatma Soliman El Sahi*, Wael Mansour Saeed, Lamiss Mohammed Abdelaziz, Gamal Ibrahim Mousa and Samar Galal Younis
  
  Background: The trial hypothesis was that short-course radiotherapy followed by near-total neoadjuvant chemotherapy would increase patient adherence to treatment compared to standard chemo-radiotherapy for locally advanced rectal cancer, without affecting oncological results. Methods: In this open-label RCT, patients with cT3, cT4, or node-positive non-metastatic rectal cancer were randomly assigned to receive complete mesorectal excision after receiving either 5*5 Gy of radiation and FOLFOX or concomitant chemo-radiotherapy and capecitabine. Adjuvant chemotherapy cycles were administered to patients using the FOLFOX regimen. The primary endpoint was to evaluate the response rate after the completion of treatment. The secondary goal was to assess the failure rate (local or distant) and treatment toxicity. Results: Of 100 patients, 50 were in arm 1 and 50 in arm 2. .. Read More»
  

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